Caffeine citrate

Benefits of Caffeine Citrate: Neurodevelopmental Outcomes of ELBW Infants

Clinical Pharmacology of Caffeine Citrate in Preterm Infants

BACKGROUND: Apnea of prematurity consists in 15 to 20 sec. of breathing cessation and is the most important disorder in the control of breathing in preterm infants. It is treated with caffeine citrate. OBJECTIVES: The objectives of this article are to review: (1) the mechanisms of action, (2) the effects, (3) the metabolism, (4) the pharmacokinetics, and (5) the adverse effects of caffeine citr...

Formulation of New Sildenafil Citrate-caffeine Orally Disintegrating Tablets: in Vitro and in Vivo Evaluation

Caffeine citrate for the treatment of apnea of prematurity: a double-blind, placebo-controlled study.

STUDY OBJECTIVE To evaluate the efficacy and safety of caffeine citrate for treatment of apnea of prematurity. DESIGN Multicenter, parallel, randomized, double-blind, placebo-controlled trial with open-label rescue. SETTING Nine neonatal intensive care units. PATIENTS Eighty-five infants, 28-32 weeks postconception and 24 hours or more after birth who had six or more apnea episodes within...

High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial.

OBJECTIVE To compare two dosing regimens for caffeine citrate in the periextubation period for neonates born at less than 30 weeks gestation in terms of successful extubation and adverse effects. DESIGN A multicentre, randomised, double blind, clinical trial. SETTING Four tertiary neonatal units within Australia. PATIENTS Infants born less than 30 weeks gestation ventilated for more than ...